Measurement of Neural Responses to Deep Brain Stimulation in Patients with Movement Disorders

For patients with movement disorders undergoing deep brain stimulation of the subthalamic nucleus, can evoked compound action potentials be measured to aid the implant procedure, programming and understanding of mechanisms of the therapy?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613000201774

Enrollment

Registered

2013-02-19

Start date

2013-03-07

Completion date

2013-03-07

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The central aim of the study is to determine if Evoked Compound Action Potentials (ECAPs) can be recorded during Deep Brain Stimulation (DBS). During the DBS lead implant procedure, specialised stimulating and recording equipment will be connected to the lead. Routine stimulation will be applied to the implanted lead electrodes and neural responses (ECAPs) will be recorded from the adjacent electrodes. Measurement of the ECAP responses may provide information to improve the implant procedure and stimulation programming, and provide information on the mechanisms of DBS.

Interventions

Recording of Evoked Compound Action Potentials during Deep Brain Stimulation of the Subthalamic Nucleus. With every stimulation pulse, nerves near the deep brain electrode respond by sending an action potential signal down the nerve. Sensitive recording equipment is used to detect and record these action potential signals as they travel past the recording electrode. The stimulation is delivered at 130 pulses/second and recording occurs on on each pulse. For this trial the stimulation and recordi

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Patients medically assessed as suitable candidates for Deep Brain Stimulation (DBS) for movement disorders. Patients implanted with a commercially available electrode lead into the STN who are part of a routine DBS implant procedure.

Exclusion criteria

Patients who have had complications during implantation such that the implanted electrodes are not able to stimulate and record in the STN

Outcome results