None listed
Conditions
Brief summary
The purpose of the study is to investigate whether the benefits of exclusive enteral nutrition (a liquid diet) seen in paediatric populations can be replicated in adult populations. The study hypothesis is that a liquid diet changes markers of gut inflammation in adults with newly diagnosed Crohn’s disease leading to clinical and biochemical remission of Crohn’s disease.
Interventions
8 week treatment with exclusive enteral nutrition (liquid diet) instead of corticosteroid therapy. The liquid diet consists of commercially available a polymeric nutrition formula. It will meet all of the participants calorie and nutrient requirements, no food or fluid other than water is allowed. It is to be taken orally, or via nasogastric tube if not tolerated orally, 6 - 8 times per day based on individual requirements.
Sponsors
University of Otago
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
16 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
newly diagnosed ileal or ileo-colonic Crohn's disease aged 16 - 40 years willing to take part able to attend multiple appointments
Exclusion criteria
active pyschological disorder possibly requires abdominal surgery
Outcome results
None listed