None listed
Conditions
Brief summary
Context: Dexmeditomedine infusion in oncology pediatric patients is used to perform repeated lumbar puncture and bone marrow aspiration. Objective: We hypothesized that dexmetomedine could be effectively used as a sedative/analgesic agent for children requiring the above procedures,We designed our study to compare the effects of dexmedetomidine infusion versus propofol infusion on perioperative hemodynamics, sedation, pain, and recovery scores for invasive procedures in pediatric oncology patients. Design: Randomised double blind study Patients or other participant: Forty ASA 1 or 2 children, 6–12 yearsr of age, with hematological cancer , were randomized to receive either propofol infusion ( Group A)or dexmedetomidine infusion (Group B) during anesthesia for diagnostic or prognostic short duration procedures . Intervention(s) : Patients were assigned to receive either Propofol infusion started at a rate of 2mg/kg over 10 min then the infusion rate of 50 ug/kg/min were adjusted until patient fall a sleep and reach a sedation score 5-6 according to Ramsay sedation score Or to receive , Dexmedetomidine infusion started at a rate of 0.5ug/kg intravenously for 10 min, Then a continous infusion of 0.5ug/kg/hr was adjusted until patient fall asleep and the sedation score became 5-6 and be able to be positioned. In both Groups, Immediately before the procedure 0.5 mg/kg Ketamine was administered intravenously .
Interventions
40 children, were randomized to receive either Propofol infusion started at a rate of 2mg/kg over 10 min then the infusion rate of 50 ug/kg/min were adjusted until patient fall a sleep and reach a sedation score 5-6 according to Ramsay sedation score .Or to receive Dexmedetomidine infusion started at a rate of 0.5ug/kg intravenously for 10 min , Then a continous infusion of 0.5ug/kg/hr was adjusted until patient fall asleep and the sedation score became 5-6 and be able to be positioned.
In bo
40 children, were randomized to receive either Propofol infusion started at a rate of 2mg/kg over 10 min then the infusion rate of 50 ug/kg/min were adjusted until patient fall a sleep and reach a sedation score 5-6 according to Ramsay sedation score .Or to receive Dexmedetomidine infusion started at a rate of 0.5ug/kg intravenously for 10 min , Then a continous infusion of 0.5ug/kg/hr was adjusted until patient fall asleep and the sedation score became 5-6 and be able to be positioned. In both groups,Immediately before the procedure 0.5 mg/kg Ketamine was administered intravenously,Then Incremental doses of Ketamine 0.3mg/kg was administered intravenously to maintain sedation score 5-6 intraoperatively.
Sponsors
Ahmad ramzy
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
Children between 6-12years. diagnosed as either acute lymphocytic leukemia or acute myeloid leukemia with ASA physical status I–II scheduled for for diagnostic or prognostic lumbar puncture or bone marrow biopsy. will be eligible for inclusion in the study.
Exclusion criteria
ASA physical status III–IV, age less than6 years or more than 12 years,congenital heart disease, cardiomyopathy, any rhythm other than sinus rhythm, liver or renal disease, upper respiratory infection, behavioral problems, patient on anticoagulant, beta blocker, clonidine, or digoxin.
Outcome results
None listed