A comparison of two different versions of Cognitive Bias Modification (CBM) plus Internet Cognitive Behavioural Therapy (iCBT) for Depression- A Randomised Controlled Trial

A randomised controlled trial comparing Internet based cognitive behavioural therapy for major depressive disorder plus a cognitive bias modification intervention (OxIGen) version A vs. Internet based cognitive behavioural therapy for major depressive disorder plus a cognitive bias modification intervention (OxIGen) version B on symptoms of depression and negative interpretation bias.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000139774

Enrollment

Registered

2013-02-05

Start date

2013-02-13

Completion date

2013-09-23

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This RCT will evaluate the acceptability and efficacy of a combined CBM + internet-based CBT program for depression by comparing an active CBM intervention with a control comparator.

Interventions

CBM (OxIGen) Active Version: Internet-based cognitive bias modification intervention with 7 sessions (1 x 20 minute session/day) of auditory scenarios delivered over 1 week. Each CBM session consists of delivery of 64 initially ambiguous scenarios that terminate with a positive resolution. + ThisWayUp Sadness Program: a 6-lesson internet-based cognitive behavioural therapy program for depression. The Sadness Program includes evidence-based content for managing depression and anxiety. Each lesson (approximately 30 minutes) must be completed prior to advancing to the subsequent lesson. Patients are given 8 weeks to complete all 6 lessons. Patients first commence the 1 week CBM component followed by the 8 week iCBT component.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Meet Diagnostic and Statistical Manual of the American Psychiatric Association - 4th edition (DSM-IV) criteria for Major Depressive Disorder, Internet access + printer access, Australian resident, Fluent in written and spoken English.

Exclusion criteria

Current substance abuse/dependence, Psychotic mental illness (Bipolar or Schizophrenia), Current or planned psychological treatment during study duration, Change in medication during last 1 month or intended change during study duration, use of Benzodiazepines, Suicidal.

Outcome results