None listed
Conditions
Brief summary
This study is intended to investigate how experimentally induced pain in the hand and elbow causes changes in the way people recognise pictures of hands/feet/cars as left or right handed. If these findings are shown to be reliable, we propose that measuring the way people recognise left and right could be used to determine what sort of pain they are feeling at that time.
Interventions
Participants will undergo 4 separate intramuscular injections of 5% hypertonic saline solution into their upper limbs (no therapeutic benefit) over 2 sessions.
There will be 2 injections per session, and the sessions will seperated by at least 1 week. The first injection in a session will be followed by the second injection by approximately 35 minutes (this time frame includes a laterality task during pain, a washout period of 10 mins, a post-pain laterality task, and a pre-pain laterality ta
Participants will undergo 4 separate intramuscular injections of 5% hypertonic saline solution into their upper limbs (no therapeutic benefit) over 2 sessions. There will be 2 injections per session, and the sessions will seperated by at least 1 week. The first injection in a session will be followed by the second injection by approximately 35 minutes (this time frame includes a laterality task during pain, a washout period of 10 mins, a post-pain laterality task, and a pre-pain laterality task). Injection sites are bilateral thenar eminences and bilateral common extensor origin (CEO) on the lateral upper forearm area. Each site will be injected once. The same bilateral locations will be injection during 1 session - eg R and L thenar eminences or R and L CEO. Participants complete a laterality recognition task before, during and after the painful stimulus. The laterality task is a computer based time response measurement programme which displays pictures of hands, feet and cars of different laterality (handedness) which have been rotated around different axes. Participants judge the laterality of each picture and input their response using the arrow keys on a keyboard. The task takes 7.5 minutes to complete when all pictures are displayed twice. The programme is also designed to ask participants to rate their pain levels (VAS) at 20 second intervals. This is also inputted using the arrow keys.
Sponsors
Unitec, NZ
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Aged 18-50 Ability to speak and write English Ability to give written, informed consent
Exclusion criteria
Orthopaedic or neurological disorders of the upper limb or neck Significant visual impairment Diagnosis of dyslexia Pain on the day of testing (chronic or acute) Use of pain medications on day of testing Trauma to upper limb Fracture/dislocation Open wounds or skin conditions Pain related conditions: Pain catastrophising (>24 on pain catatrophising scale (PCS) (Pedler, 2010)), Somatic hypervigilance (>7 on modified somatic pain questionnaire (MSPQ) (Donaldson et al., 2011)) History of fainting or seizures Diagnosis of haemophilia or other clotting disease Allergy to latex products Non-New Zealand citizens or residents
Outcome results
None listed