None listed
Conditions
Brief summary
A high salt diet is associated with an increased risk of hypertension. By contrast, in patients with type 2 diabetes, a low salt diet is associated with an increased risk for cardiovascular and total mortality. As a low salt intake may increase sympathetic nervous system (SNS) activity, we aim to determine baseline SNS activity and endothelial function in patients with diabetes consuming a habitual low salt diet and determine whether salt loading reduces SNS activity and enhances endothelial function.
Interventions
Salt loading (Slow Sodium, NaCl at a dose of 100mmol/24h in 3 divided doses) or placebo to be taken daily for 3 weeks each. Slow release salt capsules manufactured by Thompson’s compounding pharmacy.
As this is a cross over study, there will be a three week washout period between both treatment arms.
Sponsors
Dr Elif Ilhan Ekinci, Director of Diabetes
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Blood Pressure <150/80 Body Mass Index matched 2 out of 3 24 hour urine collections <150mmol/24h 35 patients will be recruited into the Type Two Diabetes arm and 35 non-diabetic patients will be recruited into the control arm.
Exclusion criteria
Other active significant medical problems, including clinical autonomic neuropathy
Outcome results
None listed