None listed
Conditions
Brief summary
We propose a randomised control study to assess the use of prophylactic Non-steroidal Anti-inflammatory Drugs for the prevention of Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis.
Interventions
Indomethacin is a Non-Steroidal Anti-inflammatory Drug (NSAID), which is commonly used to treat fever, headaches, and bone, muscular or joint pain. It works by inhibiting the production of prostaglandins (known to cause such symptoms). It is marketed under several names, including Indocid and Arthrexin.
In our study, participants will be given an Indomethacin suppository (dose given rectally) 5 minutes before the commencement of the ERCP.
We will then be monitoring our patients for 90 minutes po
Indomethacin is a Non-Steroidal Anti-inflammatory Drug (NSAID), which is commonly used to treat fever, headaches, and bone, muscular or joint pain. It works by inhibiting the production of prostaglandins (known to cause such symptoms). It is marketed under several names, including Indocid and Arthrexin. In our study, participants will be given an Indomethacin suppository (dose given rectally) 5 minutes before the commencement of the ERCP. We will then be monitoring our patients for 90 minutes post procedure for symptoms, which would suggest pancreatitis (in particular abdominal pain).
Sponsors
Vinh-An Phan
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All patients undergoing Endoscopic Retrograde Cholangiopancreatography
Exclusion criteria
-Those with active pancreatitis -Renal impairment -known allergy to non-steroidal anti-inflammatory drugs (including NSAID induced asthma) -patients with concomitant NSAID therapy (excluding Aspirin) -patients without a native papilla -Active peptic ulcer disease
Outcome results
None listed