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The effect of weight cycling on iron status, inflammation and immune function in young, overweight and obese women

The relationship between body weight and weight cycling on iron status, inflammation and immune function in young overweight and obese women: a cross-sectional study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12613000072718
Enrollment
120
Registered
2013-01-18
Start date
2006-03-02
Completion date
2010-10-29
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study examines the effect of weight cycling on iron status, inflammation and immune function. The objective is to measure iron levels, inflammation and the immune systems of young women and then investigate how weight cycling can affect these factors. This research study is part of larger trial that is comparing the effectiveness of a red meat based, low fat diet and a white meat based, low fat diet on weight loss, immune function, blood fats, glucose, insulin and iron levels.

Interventions

This is a cross-sectional study that observed weight cycling history, iron and inflammatory markers at one time point. Anthropometric data including height, weight, BMI, waist circumference, as well as body composition data including percent body fat, absolute fat mass and lean mass (using both bio-electrical impedance and dual x-ray absorptiometry measurement techniques) were collected. Self-reported history of weight cycling, weight loss and attempts at weight loss in the past five years wa

This is a cross-sectional study that observed weight cycling history, iron and inflammatory markers at one time point. Anthropometric data including height, weight, BMI, waist circumference, as well as body composition data including percent body fat, absolute fat mass and lean mass (using both bio-electrical impedance and dual x-ray absorptiometry measurement techniques) were collected. Self-reported history of weight cycling, weight loss and attempts at weight loss in the past five years was recorded. Participants were also required to undergo one blood test to measure concentration of iron, inflammatory and immune markers.

Sponsors

The University of Sydney
Lead SponsorUniversity

Eligibility

Sex/Gender
All
Age
18 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

Body mass index equal to or above 27.5 kg/m2

Exclusion criteria

Self-report of significant medical conditions (e.g. diabetes mellitus, disorders of the liver (including hemochromatosis) and kidney, autoimmune or metabolic diseases and malignancy) or use of medications that may influence weight, iron or inflammatory status; pregnancy or lactation; vegetarianism; smoking; and previous bariatric surgery. Volunteers reporting iron supplementation or blood donation within three months prior to recruitment were asked to participate only following a three month washout period

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026