None listed
Conditions
Brief summary
To study the clinical pharmacology of a number of drugs in overdose. Many medications behave differently in overdose than in clinical situations. There is limited data on the pharmacokinetics and dynamics of many new drugs in overdose. This study aims to model drug concentration and clinical effects from data collected from overdose patients
Interventions
This study is looking at the pharmacokinetics and pharmacodynamics of various drugs in overdose.
It is not an interventional study.
The aim of this research project is to study the clinical pharmacology of a number of new drugs, by modelling their concentrations and clinical effects from data collected from overdose patients.
Participants will be selected by the Prince of Wales Toxicology unit, either by the Clinical Toxicologist or Toxicology Fellow.
Drugs of interest that will be studied incl
This study is looking at the pharmacokinetics and pharmacodynamics of various drugs in overdose. It is not an interventional study. The aim of this research project is to study the clinical pharmacology of a number of new drugs, by modelling their concentrations and clinical effects from data collected from overdose patients. Participants will be selected by the Prince of Wales Toxicology unit, either by the Clinical Toxicologist or Toxicology Fellow. Drugs of interest that will be studied include any newly marketed drugs, rare but serious overdoses such as colchicine, analgesics such as paracetamol and antipsychotics. Data collected on these partcipants include drug and dose ingested, any symptoms, ECG data, drug and metabolite levels. The study will run for 5 years
Sponsors
Prince of Wales Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
Overdose in the past 24 hours with a drug
Exclusion criteria
In custody less than 14 years
Outcome results
None listed