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Comorbidities and Pre-operative Gastric Ultrasound Assessment

Preoperative fasted surgical patients undergoing gastric ultrasound assessment to determine gastric fluid volume - do comorbitities influence these gastric volumes?

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12612001216808
Acronym
CAPGU
Enrollment
243
Registered
2012-11-16
Start date
2012-11-28
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The inhalation of gastric (stomach) contents in to the lungs (pulmonary aspiration) has significant morbidity and mortality and can attribute to up to 9% of anaesthetic related deaths. [1] [2] In a large retrospective analysis, pulmonary aspiration occurs between 1:900 emergency patients and one in 3900 elective patients [3] A key risk factor for pulmonary aspiration is the volume of the aspirated gastric content. In certain subgroups of patients such as those with trauma, pulmonary aspiration can be as high has 34%. [4] Preoperative fasting guidelines aim to reduce the risk of pulmonary aspiration for the majority of patients undergoing anaesthesia. This is normally 6 hours for solid food and 2 hours for clear fluids in our institution (Royal Perth Hospital). Despite these guidelines there remain high risk groups in whom significant residual gastric volumes can remain despite adequate fasting - this is because they take longer to clear their gastric contents. These include patients with diabetes, liver or kidney dysfunction or pregnancy and trauma patients. [5] Previous methods for determining gastric content preoperatively have been invasive and lengthy procedures. Non-invasive gastric ultrasound however can now reliably estimate gastric volume and content. [5] [6] Ultrasound represents a convenient bedside portable tool that can be used to help guide anaesthetists managing the anaesthetic risk for these high risk groups. This prospective cohort study aims to quantify the risk of aspiration by gastric volumes for those with renal dysfunction, emergency or urgent surgery, diabetes, gastro-oesophageal reflux disease (GORD) and obesity as indicated by preoperative gastric ultrasound using a standardised technique [1, 5] 1. Perlas, A., et al., Ultrasound assessment of gastric content and volume. Anesthesiology. 111(1): p. 82-9. 2. Landreau, B., I. Odin, and N. Nathan, [Pulmonary aspiration: epidemiology and risk factors]. Ann Fr Anesth Reanim, 2009. 28(3): p. 206-10. 3. Warner, M.A., M.E. Warner, and J.G. Weber, Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology. 1993. 78(1): p. 56-62. 4. Lockey, D.J., T. Coats, and M.J. Parr, Aspiration in severe trauma: a prospective study. Anaesthesia. 54(11): p. 1097-8. 5. Perlas, A., et al., Gastric sonography in the fasted surgical patient: a prospective descriptive study. Anesth Analg, 2011. 113(1): p. 93-7.

Interventions

Ultrasound scan of gastric antrum . This involves placing ultrasound jelly on the epigastric area of the patient then placing a curvilinear ultrasound plastic probe on the epigastric area of the abdomen to produce a picture of the gastric antrum - this is done with the patient in the lateral decubitus position (on their side). The scan will take a duration of circa 2 minutes which can approximate total gastric fluid volume using a validated formula

Sponsors

Dr James Walker
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

ASA (american society of anaesthesiologists) grade 1-3 Starvation times more than 2 hours for clear fluids and 6 hours for food Please see exclusion criteria... gastrointestinal abnormalities are excluded and also those who have had gastrointestinal surgery previously as this distorts the gastric antrum. All surgical specialities will be included aside from cardiothoracic patients.

Exclusion criteria

Previous gastro-oesophageal surgery or abnormality of the gastrointestinal tract Recent Pregnancy (within 3 months) Age less than 18 Unable to give informed consent themselves Hiatus Hernia Patients who have not been starved for food fo 6 hours and clear fluids for more than 2 hours Cognitive impairement/ mental disability Those unable to lie still for ultrasound assessment Cardiothoracic surgery

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026