Diffuse Brainstem Glioma Tumour Study: developing new treatment strategies for Diffuse Pontine Glioma

Post mortem tumour donation for Diffuse Intrinsic Pontine Glioma – developing DIPG cell cultures to test novel therapeutic strategies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612001183875

Acronym

HoTRODS

Enrollment

Registered

2012-11-07

Start date

2012-11-07

Completion date

Unknown

Last updated

2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The main goal of the study is to grow cells in the laboratory from tumours of patients with diffuse brainstem glioma and similar brainstem tumours. The aim of the results of the study is to help develop new and better treatments for patients with these types of tumours and help in choosing the right treatment for each patient and be able to predict which patients are more likely or not to respond to a certain type of treatment

Interventions

This is a tumour biology study whereby tumour and constitutional tissue samples from participating sites in Australia with diffuse pontine glioma (DIPG) and other types of brainstem gliomas will be collected at autopsy, culture the DIPG cells in vivo and perform a screen of 10,000 small molecules that specifically inhibit diffuse pontine glioma propagation and identify these molecules to develop new treatment strategies for Diffuse Pontine Glioma.

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

1. Patients of any age with clinical and radiological diagnosis of diffuse brainstem glioma OR 2. Patients with diffuse midline gliomas not involving the brainstem OR 3. Patients with high grade gliomas in other locations 4. Patients with other histologies may be included only after discussion with the study chair

Exclusion criteria

1. Patients with low grade gliomas

Outcome results