A clinical trial of non-invasive stimulation to the cerebellum for cervical dystonia

A clinical trial of non-invasive stimulation to the cerebellum for cervical dystonia to assess symptoms and the impact on a person's life

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001182886

Enrollment

Registered

2012-11-07

Start date

2013-01-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The trial is a randomised controlled study into the effect of applying non-invasive brain stimulation to the cerebellum on the symptoms of cervical dystonia.

Interventions

The intervention is theta-burst stimulation. This is a form of repetitive transcranial magnetic stimulation (TMS) delivered in a patterned style that can increase or decrease excitability of brain tissue. Theta-burst stimulation will be delivered at a low intensity (80% of active motor threshold of target muscles). 600 pulses are delivered in an intermittent pattern, taking about 3 minutes. The stimulation will be delivered to each cerebellar hemisphere, with a 2 minute break between sides. The

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

Diagnosis of cervical dystonia by a neurologist No botulinum toxin injections in last 10 weeks Over 18 years of age No contraindiations to Transcranial Magnetic Stimulation (TMS) or theta-burst stimulation (TBS)

Exclusion criteria

Contraindications to TMS Epilepsy Neurological or musculoskeletal conditions affecting the neck

Outcome results