Comparison between Gallium-68 citrate Positron Emission Tomography (PET-CT) and Gallium-67 citrate Single Photon Emission Computed Tomography (SPECT-CT) for infection imaging

Comparison between Gallium-68 citrate Positron Emission Tomography (PET-CT) and Gallium-67 citrate Single Photon Emission Computed Tomography (SPECT-CT) in participants with suspected bone and joint infections or fever of unknown origin.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001166864

Enrollment

Registered

2012-11-02

Start date

2012-11-29

Completion date

2014-08-25

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to compare Gallium-68 citrate PET-CT with Gallium-67 citrate SPECT-CT, the current standard of care, for diagnosis in patients with suspected bone/joint infection or with pyrexia of unknown origin (PUO). Image quality and reporter confidence with Ga-68 PET-CT will be assessed and the cost-benefit of routine Ga-68 citrate PET-CT compared to Ga-67 SPECT-CT will be evaluated. On completion of the study an informed recommendation for future infection imaging protocols for bone/joint infections and PUO will be made based on clinical efficacy and cost-benefit analysis.

Interventions

A single Gallium -68 citrate PET-CT will be performed in addition to the routine Gallium -67 SPECT-CT study. In participants with fever of unknown origin, approximately 98 MBq of Ga-68 citrate will be administered intravenously. After a minimum of 60 minutes following injection, whole body PET-CT imaging will be performed on Siemens PET-CT, image reconstruction will include CT attenuation correction. For participants with suspected bone/joint infection approximately 135 MBq of Ga-68 citrate will be administered intravenously. After a minimum of 60 minutes following injection, PET-CT imaging of the region of interest will be performed on Siemens PET-CT, image reconstruction will include CT attenuation correction. The Gallium -68 citrate PET-CT and the Gallium -67 SPECT-CT scan will be performed ideally within 48-72 hours of each other. Patients will be followed for up to 3 months to record subsequent treatment regimens: antibiotics, surgery, radiological and clinical responses to therapy and biopsy results when performed.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Presents with PUO or suspected bone/joint infection Able to undergo study procedures Able to provide informed consent

Exclusion criteria

Under 18 years Pregnant or lactating at the time of SPECT-CT and PET-CT scan/s Unable to provide informed consent.

Outcome results