None listed
Conditions
Brief summary
The purpose of this study is to improve visual outcomes for patients who suffer with glaucoma. This outcome is known as contrast sensitivity. Glaucoma: is a disease in which the optic nerve is damaged, leading to progressive, irreversible loss of vision. It is often, but not always, associated with increased pressure of the fluid in the eye. The purpose of this study is to establish a proof of a principle known as neuroprotection. Neuroprotection: refers to the ability to directly promote survival of the optic nerve. The optic nerve is the nerve that transmits visual information from the retina to the brain. Contrast sensitivity: is the ability to differentiate between light and dark (contrast).
Interventions
Treatment: The study eye will receive a drop of sterile 50% glucose (10 Microlitres) every 5 minutes for one hour. Pain and discomfort will be assessed through out the period of treatment. It will be assessed on a pain scale of 1 to 10. 1 being nil pain and 10 being the worst pain. This will be documented in the patient's case notes.
Sham control: on another visit separated by at least one week, the same patients will receive a saline drop in the same manner, and undergo the same tests. (The o
Treatment: The study eye will receive a drop of sterile 50% glucose (10 Microlitres) every 5 minutes for one hour. Pain and discomfort will be assessed through out the period of treatment. It will be assessed on a pain scale of 1 to 10. 1 being nil pain and 10 being the worst pain. This will be documented in the patient's case notes. Sham control: on another visit separated by at least one week, the same patients will receive a saline drop in the same manner, and undergo the same tests. (The optic disc photo is important to record the subtype of glaucomatous optic neuropathy in case there is a clear pattern, but does not need repeating.)
Sponsors
Royal Adelaide Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Group A Inclusion Criteria: Age 50 years or older Pseudophakic, moderate to severe glaucoma (MD < -6) Visual acuity logMAR < 1.0 Group B Inclusion Criteria: Age 50 years or older Pseudophakic Visual acuity logMAR < 1.0
Exclusion criteria
Group A Exclusion Criteria: History of diabetes mellitus Group B History of diabetes mellitus Glaucoma
Outcome results
None listed