None listed
Conditions
Brief summary
The study will evaluate the effects of a D-xylose preload, with or without sitagliptin, on incretin hormone secretion, gastric emptying, and postprandial glycaemia in patients with type 2 diabetes.
Interventions
Each subject will undergo four study visits, in which they will receive a sweet "preload" drink, containing either 50g D-xylose or 80mg sucralose (negative control), after receiving either 100mg sitagliptin or placebo. The four studies will occur in double-blind, randomised fashion, separated by 3 days. Sitagliptin or placebo tablets will be taken at 2200 the evening before each study, and the sweet preload will be consumed the following morning, between T=-40 to -38 min, before a mashed potato
Each subject will undergo four study visits, in which they will receive a sweet "preload" drink, containing either 50g D-xylose or 80mg sucralose (negative control), after receiving either 100mg sitagliptin or placebo. The four studies will occur in double-blind, randomised fashion, separated by 3 days. Sitagliptin or placebo tablets will be taken at 2200 the evening before each study, and the sweet preload will be consumed the following morning, between T=-40 to -38 min, before a mashed potato meal (65g powdered potato and 20g glucose reconstituted with 200mL water and one egg yolk containing 13C octanoic acid) consumed between T=0 to 5 min.
Sponsors
Royal Adelaide Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients with type 2 diabetes mellitus
Exclusion criteria
Medications affecting gut function; Alcohol intake >20g daily or cigarette smoking; Significant gastrointestinal disease or surgery; Impaired liver or renal function; Blood donation within 3 months
Outcome results
None listed