The expression of Transient receptor potential melastatintype 2(TRPM2) in the immunocytes of sepsis patients and the role of TRPM2 in the development of sepsis

Increased expression of Transient receptor potential melastatintype (TRPM2) in monocyte and lymphocyte promote the inflammtory cytokines production and lymphocytic apoptosis in sepsis patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612001114831

Enrollment

Registered

2012-10-18

Start date

2012-10-21

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to find the role of TRPM2 in the development of sepsis. We hypothesis that the TRPM2 mRNA increase in the monocyte and lymphocyte in sepsis patients. TRPM2 has correlation with inflammatory cytokines production and lymphocyte apoptosis. TRPM2 modulation may be a new method to cure sepsis.

Interventions

10 ml blood drawn from each patient. The plasma, monocyte and lymphocyte will be separated from this 10 ml blood. We only draw 10 ml blood within 24 hours after diagnosis of sepsis

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

sepsis patients including sepsis, severe sepsis and sepsis shock patients.

Exclusion criteria

Not sepsis patients

Outcome results