PAV + VENTILATION TRIAL- A Randomised Controlled trial comparing Proportional Assist Ventilation (PAV+) ventilation and pressure support ventilation in patients eligible for spontaneous ventilation.

PAV + VENTILATION TRIAL- A Randomised Controlled trial comparing Proportional Assist Ventilation (PAV+) ventilation and pressure support ventilation in patients eligible for spontaneous ventilation

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001097831

Enrollment

100

Registered

2012-10-16

Start date

2012-11-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The trial is a trial comparing two modes of mechanical weaning in patients in ICU who are eligible for weaning from mechanical ventilation

Interventions

Patients who have been ventilated for > 48hrs and are suitable for spontaneous breathing will be randomised into either; Arm 1.Proportional Assist Ventilation ( PAV+) ventilation or Arm 2. Pressure Support ( PS) ventilation arm. Once assigned to either the PAV+arm or PS arm the patients will remain on their assigned mode of ventilation throughout the duration of their mechanical weaning. The duration of each participants' mechanical weaning will differ on a case by case basis. The PAV+ intervention differs from the standard PS treatment in that the software in the ventilator delivering PAV+ mode of ventilation measures resistance and elastance of the airway.Studies suggest this software may improve patient ventilator synchrony.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

All patients ventilated on Puritan Bennett ventilator with PAV+ software who have been ventilated for at least 48 hours on a mode other than PAV+ or PS, and deemed ready for spontaneous ventilation

Exclusion criteria

Patients who are not likely to survive 24 hours Patients admitted for palliation Patients who are brain dead Patients with hypoxic brain injury Patients with a tracheostomy Patients with neuromuscular injury or disease process Unable to obtain consent/assent

Outcome results