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Pupil fatigue: effectiveness of pupil-dilating drops

Effectiveness of mydriatic drops on Dunedin Hospital Eye Department patients, when used on consecutive days

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12612001091897
Enrollment
90
Registered
2012-10-12
Start date
2012-11-02
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study seeks to determine if the effectiveness of pupil-dilating drops is affected by their use the previous day

Interventions

Participants will have pupil diameters measured using an infrared video pupillometer, and then have one drop of either a) tropicamide 1% alone, b) tropicamide 1% and phenylephrine 2.5% a few seconds apart, or c) cyclopentolate 1% and phenylephrine 2.5% a few seconds apart, instilled into one eye. After an appropriate delay to allow action of the mydriatic agent (30 minutes except for cyclopentolate = 60 minutes), pupillometry will be performed again. All participants except group c) (the 'contr

Participants will have pupil diameters measured using an infrared video pupillometer, and then have one drop of either a) tropicamide 1% alone, b) tropicamide 1% and phenylephrine 2.5% a few seconds apart, or c) cyclopentolate 1% and phenylephrine 2.5% a few seconds apart, instilled into one eye. After an appropriate delay to allow action of the mydriatic agent (30 minutes except for cyclopentolate = 60 minutes), pupillometry will be performed again. All participants except group c) (the 'control' group) will return the following day to have pupillometry performed again, then one drop each of cyclopentolate 1% and phenylephrine 2.5% will be instilled, and pupillometry repeated after 60 minutes.

Sponsors

University of Otago
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients of the Dunedin Hospital Eye Department

Exclusion criteria

Previous surgery on study eye On regular eye drops History of intraocular inflammation in study eye History of traumatic damage or congenital abnormality of anterior segment of study eye Narrow drainage angles Poorly controlled hypertension (>160/90mmHg) Tachycardia (>90bpm) Cardiac disease Allergy to topical agents used in this study Any physical or cognitive disability that prevents understanding or cooperation with requirements of study

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026