None listed
Conditions
Brief summary
This study seeks to determine if the effectiveness of pupil-dilating drops is affected by their use the previous day
Interventions
Participants will have pupil diameters measured using an infrared video pupillometer, and then have one drop of either a) tropicamide 1% alone, b) tropicamide 1% and phenylephrine 2.5% a few seconds apart, or c) cyclopentolate 1% and phenylephrine 2.5% a few seconds apart, instilled into one eye. After an appropriate delay to allow action of the mydriatic agent (30 minutes except for cyclopentolate = 60 minutes), pupillometry will be performed again. All participants except group c) (the 'control' group) will return the following day to have pupillometry performed again, then one drop each of cyclopentolate 1% and phenylephrine 2.5% will be instilled, and pupillometry repeated after 60 minutes.
Sponsors
Study design
Eligibility
Inclusion criteria
Patients of the Dunedin Hospital Eye Department
Exclusion criteria
Previous surgery on study eye On regular eye drops History of intraocular inflammation in study eye History of traumatic damage or congenital abnormality of anterior segment of study eye Narrow drainage angles Poorly controlled hypertension (>160/90mmHg) Tachycardia (>90bpm) Cardiac disease Allergy to topical agents used in this study Any physical or cognitive disability that prevents understanding or cooperation with requirements of study