None listed
Conditions
Brief summary
NAFLD is a common liver disease associated with obesity and insulin resistance. There is no drug therapy and while there is general consensus that lifestyle intervention is effective at reducing steatosis our understanding of the distinct roles of diet and exercise on liver injury remains unclear. This study assesses the histological and metabolic effects of 6 months circuit exercise training compared with diet-induced weight loss in overweight patients with NAFLD.
Interventions
A group based circuit exercise training program (EX) (without changes to dietary intake), supervised by an exercise physiologist, involving one hour of training three times per week for six months. The circuit training consists of 15 resistance exercises with training intensity fixed at 50% of one repetition maximum (1-RM), reassessed monthly. The 1-RM test involves the participant lifting the heaviest weight possible whereby they can perform only 1 repetition. This weight is then halved and set
A group based circuit exercise training program (EX) (without changes to dietary intake), supervised by an exercise physiologist, involving one hour of training three times per week for six months. The circuit training consists of 15 resistance exercises with training intensity fixed at 50% of one repetition maximum (1-RM), reassessed monthly. The 1-RM test involves the participant lifting the heaviest weight possible whereby they can perform only 1 repetition. This weight is then halved and set as the weight used for the training session. This assessment is individualised for each muscle group and repeated monthly so that any increases in strength (1-RM) during the program are accounted for and the intensity remains stable at 50% 1-RM relative to improving strength.
Sponsors
Princess Alexandra Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Biopsy proven Nonalcoholic fatty liver disease BMI>25kg/m2 Non-diabetic
Exclusion criteria
Exclusion criteria included the presence of other liver diseases or evidence of cirrhosis, alcohol consumption > 40 g/day (males) or > 20 g/day (females), and diabetes
Outcome results
None listed