None listed
Conditions
Brief summary
Clonidine has been effectively used as a non-opioid (morphine-like) pain killer and sedative in a variety of clinical settings for many years. The Analgesia Nociceptive Index (ANI) monitor is a novel anaesthetic monitor that has been developed for use with opioid based pain killers. It works by assessing (primarily) heart rate variability to generate a score which gives an indication of nociceptive (painful) inputs. This study aims to examine the effects of clonidine on the ANI under general anaesthesia for laparoscopic cholecystectomy, as part of the pain relieving strategy
Interventions
Patients will receive a standardised protocol for induction of anaesthesia with fentanyl, propofol and rocuronium. . A standard IV paracetamol 1g and IV Parecoxib 40mg (if no contraindication) are also given. Analgesia Nociception Index (ANI) will be recorded at every 5 minute intervals. IV Clonidine 1mcg/kg will be given 5 mins following pneumoperitoneum. Any further dose of fentanyl given will be recorded
Sponsors
fremantle Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Laparoscopic cholecystectomy
Exclusion criteria
unable to consent below 18 years old Established arrhythmias Allergy/sensitivity to clonidine diabetes mellitus and autonomic neuropathy sepsis/ emodynamic instability chronic pain
Outcome results
None listed