None listed
Conditions
Brief summary
The research project is aiming to understand how the body controls appetite (that is how hungry and how full we feel) after we consume foods that are made up of the main nutrients carbohydrate, protein and fat. We are also aiming to understand if this appetite control process is disrupted in adolescents who are obese compared with adolescents who are of a healthy weight. This information will be beneficial to be able to provide nutritional advice and strategies to help with the treatment and prevention of obesity in childhood.
Interventions
Macronutrient specific meal- High carbohydrate or high protein in obese children.
The breakfast meals will be a milkshake. The energy content of the milkshake will be 25% of the participant's estimated energy requirements. The high carbohydrate will consist of 6%protein, 16% fat, 75% carbohydrate. The high protein will consist of 55% protein, 15% fat and 28% carbohydrate.
There will be two study mornings. On the first morning they will receive either one of two study breakfasts (high car
Macronutrient specific meal- High carbohydrate or high protein in obese children. The breakfast meals will be a milkshake. The energy content of the milkshake will be 25% of the participant's estimated energy requirements. The high carbohydrate will consist of 6%protein, 16% fat, 75% carbohydrate. The high protein will consist of 55% protein, 15% fat and 28% carbohydrate. There will be two study mornings. On the first morning they will receive either one of two study breakfasts (high carbohydrate or high protein). They will then be asked to come back on a second morning after a minimum of 1 week washout to cross over and receive the alternate study meal.
Sponsors
Dr Kate Huggins
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
11 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
*Healthy weight - body mass index (BMI) within the 15th – 85th percentile for age and sex. *Healthy obese - BMI > or = to 95th percentile for age and sex. *Non smoking *NOT taking medications or drugs known to alter body composition or metabolism, including insulin sensitisers, glucocorticoids, thyroxin *NOT have obesity due to secondary causes relating to genetic disorders (e.g Prader-Willi syndrome, Down’s syndrome) or endocrinology-related disorders (e.g. hypothyroidism or growth hormone deficiency) *NOT have lactose intolerance or follow any severely restricted diets or have complex food allergies
Exclusion criteria
Taking medications or drugs know to alter body composition or metabolism, including insulin sensitisers, glucocorticoids, thyroxin. Obesity due to secondary causes relating to genetic disorders (e.g Prader-Willi syndrome, Down’s syndrome) or endocrinology-related disorders (e.g. hypothyroidism or growth hormone deficiency) Those following severely restricted diets, such as those for complex allergies.
Outcome results
None listed