Evaluating the role of Positron Emission Tomography (PET) scanning as a non invasive technique to diagnose graft vs host disease of the gastrointestinal tract following bone marrow transplantation.

A Pilot Study of Non Invasive Assessment of Acute Graft vs Host Disease of the Gastrointestinal Tract and Treatment Response Following Allogeneic Haemopoetic Stem Cell Transplantation using 18F-FDG PET.

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001053819

Enrollment

Registered

2012-10-03

Start date

2010-04-06

Completion date

2014-11-27

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study is evaluating whether a diagnostic technique, known as PET scanning, can provide a non invasive means of evaluating the presence of acute graft vs host disease of the gastrointestinal tract following bone marrow transplantation. Who is it for? You may be eligible to join this study if you are aged above 18 years and have suspected acute graft vs host disease of the gastrointestinal tract following bone marrow transplantation. Trial details All participants in this trial will undergo a positron emission tomography (PET) scan at the time acute graft vs host disease of the gastrointestinal tract is suspected. A PET scan involves injection of a small amount of radioactive tracer into the bloodstream followed by scanning of the whole body in a machine that looks similar to a CT scan machine for approximately 30 minutes. In addition, participants will undergo standard care, which involves a gastroscopy and colonoscopy where biopsies of the gastrointestinal tract are obtained to assess whether graft vs host disease is present or not. This study will help us to determine whether PET scanning can accurately assess non invasively the presence of acute graft vs host disease of the gastrointestinal tract following bone marrow transplantation.

Interventions

Patients with clinically suspected acute graft vs host disease of the gastrointestinal tract following bone marrow transplantation will have a positron emission tomography (PET) scan to determine whether this non invasive technique is useful to detect the condition. The PET scan takes approximately 30 minutes to complete.

Study design

Allocation

Non-randomised trial

Primary purpose

Diagnosis

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

Clinical Suspicion of acute Graft vs Host disease of the gastrointestinal tract Day 20-180 post allogeneic bone marrow transplantation

Exclusion criteria

Commencement of therapy for suspected acute graft vs host disease of the gastrointestinal tract prior to PET scanning Significant uncontrolled intercurrent illness Lactating or pregnant

Outcome results