Intraoperative fluid optimization of patients undergoing total hip or knee arthroplasty using pulse pressure variation obtained by a continuous noninvasive blood pressure monitor

The influence of fluid optimization using pulse pressure variation obtained by continuous noninvasive blood pressure monitor compared to standard perioperative pressure driven fluid management in the patients undergoing total hip or knee replacement under general anesthesia on the postoperative morbidity (number and rate of complications and length of stay)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001014842

Enrollment

Registered

2012-09-20

Start date

2012-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Aim of the trial is to evaluate the possibility of goal-directed fluid therapy during major orthopedic procedures under general anesthesia using protocol based on pulse pressure variation obtained by noninvasive continuous arterial pressure monitoring in comparison to standard usually given care. Influence on the postoperative outcome (number and rate of complications and hospital length of stay) will be assessed.

Interventions

Fluid optimization guided by the pulse pressure variation obtained by continuous noninvasive arterial pressure monitor (CNAP) based on the volume clamp method in addition to standard pressure/clinical signs based fluid management during the surgical procedure.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

elective hip or knee arthroplasty, general anesthesia, regular heart rhythm, given and signed informed consent

Exclusion criteria

obvious perfusion abnormality on the side of measurement, vascular implants on the side of measurement, known neuronal or neuromuscular disease of upper extremities, peripheral edema

Outcome results