None listed
Conditions
Brief summary
Chronic Rhinosinusitis is a chronic condition of the nose and paranasal sinuses. Patients suffering from chronic sinusitis complain of headaches, nasal congestion and thick nasal discharge. The burden of chronic sinusitis on our society is high. It causes increased cost to health care system and decreased productivity with loss of work days. No single treatment was found to control the symptoms of chronic sinusitis. It was found that dry mannitol delivered to the lungs of patients with cystic fibrosis makes the secretions less thick, easier to clear and symptoms better controlled. We believe these effects are transferrable to chronic sinusitis patients. We believe that mannitol will help loosen their nasal discharge, making it easier to clear and eventually control their symptoms better
Interventions
Dry mannitol powder (a natural product), delivered intranasally, along with standard medical care (listed below). Mannitol dosing:s 150 mg/puff, patients will be guided to use it as 3 nasal puffs in each nostril three times per day for 6 months
Sponsors
Dr Emad Massoud
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Patients with chronic rhinosinusitis (as defined by the Canadian clinical practice guidelines for acute and chronic sinusitis)
Exclusion criteria
Previous sinus surgery Allergy or sensitivity to any of the items in the standard medical treatment
Outcome results
None listed