Comparison of the efficacy and safety of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris; a clinical trial

A randomized, double-blind, clinical trial to compare the efficacy (lesion number), side effects, and patient's satisfaction rate of topical adapalene and benzoyl peroxide in the cases with mild acne vulgaris

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001006831

Enrollment

Registered

2012-09-18

Start date

2011-01-01

Completion date

2012-04-06

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The present clinical trial aims to compare the efficacy and safety profile of topical adapalene 0.1% and BPO 2.5% gels in patients with mild acne vulgaris. For this purpose, 60 patients equally received either topical adapalene 0.1% gel or topical BPO 2.5% gel once daily to the entire face (except periocular area and lip) for two consecutive months. Three months later, number of lesions, side effects and patients' satisfaction were compared between the two groups.

Interventions

Patients received topical adapalene 0.1% gel (ADA; Differin; Galderma, Watford, UK) once daily for 8 weeks.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

Diagnosis of acne vulgaris Mild disease according to the Evaluator Global Severity Score (grade 2)

Exclusion criteria

Severe acne vulgaris Any dermatologic conditions requiring systemic therapy Nursing/pregnant women The women were planning for pregnancy

Outcome results