Effects of common sleeping pills on arousal and muscle function during sleep

Effects of common sedatives on respiratory arousal and upper airway muscle function during sleep in healthy men and women with and without sleep apnoea

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612001004853

Acronym

Nil

Enrollment

Registered

2012-09-18

Start date

2012-09-27

Completion date

2015-08-26

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this physiology study is to examine the effects of common sleeping pills (sedatives) on the awakening (arousal) response to respiratory stimuli during sleep and their effects on upper airway muscles, airway function, and breathing responses during sleep.

Interventions

Arm 1: temazepam (10mg), once only immediately before going to bed, taken orally Arm 2 zopiclone (7.5mg), once only immediately before going to bed, taken orally Arm 3: zolpidem (10mg), once only immediately before going to bed, taken orally 1 week washout between treatments

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy men and women with and without sleep apnoea

Exclusion criteria

-Known allergy or previous adverse reaction to temazepam, zopiclone or zolpidem -Medications known to affect muscle activity or sleep -Pregnant or nursing mothers

Outcome results