The role of fluorescence in situ hybridization (FISH) in the early detection of bladder cancer using Photodynamic diagnosis (PDD)

The role of fluorescence in situ hybridization (FISH) in the early detection of bladder cancer using PDD

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000947808

Enrollment

Registered

2012-09-05

Start date

2013-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The percentage of the false positive lesions in photodynamic diagnosis (PDD) ranges between 7,1% and 47% in the literature. Careful interpretation and indication of PDD is necessary in case of previous instillation therapy especially with BCG and false positive rates of 64%. Whether histologically proven false positive fluorescence is caused by early malignant genetic changes has been discussed but is still the object of research..

Interventions

A multicolour-fluorescence in situ hybridization (FISH) approach will be performed on a liquid-based washing urinary cytology and on suspicious lesions in all participants. This will be performed once in all cases. The duration of fluorescence in situ hybridization and the histopathologic evaluation will be performed by our uro-pathologist. They will each last approximately two days. It will neither mean longer hospitalization nor more than the usual tissue specimens for all patients.

Eligibility

Sex/Gender

All

Age

21 Years to 99 Years

Healthy volunteers

Inclusion criteria

urothelial carcinoma of the bladder

Exclusion criteria

none

Outcome results