dexamethasone and tramadol as additives to local anesthetics in ultrasound guided supraclavicular brachial plexus (SCBP) block and duration of analgesia.

The effect of tramadol or dexamethasone added to lidocaine for a ultrasound guided supraclavicular brachial plexus (SCBP) block on the onset, duration of sensory and motor blockade and first request of analgesia.

Status

Terminated

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000921886

Enrollment

Registered

2012-08-29

Start date

2012-09-01

Completion date

2014-03-17

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

During nerve blocks (which can control postoperative pain effectively), various drugs have been proposed in combination with local anesthetics (LA) to help reduce onset time and to prolong the duration of action and postoperative analgesia. Clonidine, epinephrine, and opioids are such examples but they are not without side effects. Tramadol and dexamethasone was proposed as safe adjuvents to LA but there were no study comparing those two molecules in ultrasound guided (US) peripheral nerve blocks.

Interventions

15 ml lidocaine 2% + 8 mg dexamethasone in single shot ultrasound guided supraclavicular brachial plexus block.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

patients undergoing upper limb wrist/hand/elbow or distal arm surgery

Exclusion criteria

history of lung disease, obesity (body mass index > 30 kg/m2), a history of chronic pain or psychiatric disorder, drug or alcohol abuse, and hypersensitivity to local anesthetics

Outcome results