Sevoflurane aggravate minimal hepatic encephalopath in cirrhosis patients

Sevoflurane aggravate minimal hepatic encephalopathy in cirrhosis patients compared to propofol

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000910808

Enrollment

Registered

2012-08-27

Start date

2012-01-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Patients with minimal hepatic encephalopathy (MHE) have impaired motor function and visuomotor cordination, which make them unsafe in their life. Evaluation of MHE stage in surgery patients with hepatic cirrhosis is an important problem for the inhalation of anesthetics. We have previously observed that sevoflurane induced increased MHE scores in non-hepatic surgery patients with cirrhosis, suggesting that inhaled anesthetics can. In this study, we try to demonstrate the effect of sevoflurane on MHE in cirrhosis patients by a randomized controlled clinical observation. This study would be helpful for the perioperative anesthetic application in patients with cirrhosis.

Interventions

2-3% sevoflurane (to maintain bispectral index values 40-60) inhaled during the operation (2-4h, vary on a case by case basis depending on the operation).

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

patients who had evidence of cirrhosis by clinical, biochemical, and/or histological criteria with ASA class 1 or 2 scheduled for elective surgery

Exclusion criteria

patients with active bleeding or with overt encephalopathy, patients with known allergy to sedative, known significant respiratory disease, active neurological impairment, advanced or decompensated liver disease (CP score >9, Child-Pugh class C), ongoing alcohol or drug abuse, psychiatric illness, monocular vision, mental impairment.

Outcome results