None listed
Conditions
Brief summary
Measurement of neuroprostane and isofuran levels in plasma and CSF may give prognostic information in traumatic brain injury. The study aims are: 1) To establish the correlation between plasma and CSF levels of these markers in a population of severely brain injured patients and 2) To establish correlation between neuroprostane and isofuran levels and outcome as measured by glasgow outcome score and anterograde amnesia score.
Interventions
This is a prospective observational study. All patients with a severe brain injury and intracranial pressure monitoring will be included. Blood alone ( ARM 1 ) or blood and cerebrospinal fluid ( ARM 2) will be collected on days 1, 3, 5 and 7. Arm 1 - Sampling of Plasma (patients with ICP monitoring via Codman indwelling transducer)
Arm 2 - Sampling of CSF and Plasma (patients with an external ventricular drain). Values will be compared with those from historical controls who healthy age and gend
This is a prospective observational study. All patients with a severe brain injury and intracranial pressure monitoring will be included. Blood alone ( ARM 1 ) or blood and cerebrospinal fluid ( ARM 2) will be collected on days 1, 3, 5 and 7. Arm 1 - Sampling of Plasma (patients with ICP monitoring via Codman indwelling transducer) Arm 2 - Sampling of CSF and Plasma (patients with an external ventricular drain). Values will be compared with those from historical controls who healthy age and gender matched patients having subarachnoid anaesthesia and who have provided us wth their CSF
Sponsors
Neurotrauma research program of WA institute of medical research
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Traumatic brain injury requiring Intracranial Pressure Monitoring
Exclusion criteria
Unlikely to survive the first 24 hours of hospitalisation
Outcome results
None listed