Skip to content

Non invasive end tidal carbon dioxide monitoring study in patients presenting to the Emergency Department with an Acute Respiratory Illness: establishing whether there is a correlation between arterial blood gas and non-invasive monitored, carbon dioxide levels.

To determine whether we can substitute the invasive arterial blood gas measurement of CO2 with a non-invasive oral nasal cannula in patients presenting to the Emergency Department with acute respiratory illness

Status
Terminated
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12612000895886
Acronym
NIET-CO2 Study
Enrollment
139
Registered
2012-08-22
Start date
2013-01-21
Completion date
2013-06-11
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Blood gas monitoring, especially carbon dioxide (CO2), is often needed for the appropriate management of patients with acute respiratory illnesses in the Emergency Department. Currently, the only accepted method to monitor CO2 is via arterial blood gas sample, however, repeated arterial blood sampling is invasive, causes patient discomfort, and fails to provide a continuous picture of changes in blood gas levels, in response to therapeutic interventions. Measuring oxygen saturation and carbon dioxide continuously provides more information about changes than single arterial measurements. This study will monitor CO2, using a non-invasive oral nasal cannula attached to a monitor and compare this to the traditional arterial CO2 reading. A CO2 reading will be recorded at the same time that a blood gas is taken, to see if there is a correlation between non invasive CO2 (NIET-CO2) and ABG results.

Interventions

Blood gas monitoring, especially carbon dioxide (CO2), is often needed for the appropriate management of patients with acute respiratory illnesses in the Emergency Department. Currently, the only accepted method to monitor CO2 is via arterial blood gas sample, however, repeated arterial blood sampling is invasive, causes patient discomfort, and fails to provide a continuous picture of changes in blood gas levels, in response to therapeutic interventions. Measuring oxygen saturation and carbon di

Blood gas monitoring, especially carbon dioxide (CO2), is often needed for the appropriate management of patients with acute respiratory illnesses in the Emergency Department. Currently, the only accepted method to monitor CO2 is via arterial blood gas sample, however, repeated arterial blood sampling is invasive, causes patient discomfort, and fails to provide a continuous picture of changes in blood gas levels, in response to therapeutic interventions. Measuring oxygen saturation and carbon dioxide continuously provides more information about changes than single arterial measurements. This study will monitor CO2, using a non-invasive oral nasal cannula attached to a monitor and compare this to the traditional arterial CO2 reading. A CO2 reading will be recorded at the same time that a blood gas is taken, to see if there is a correlation between non invasive CO2 (NIET-CO2) and ABG results. Each session will last approximately 15 minutes, and the patient may be involved in more than one session, if as part of their routine care they have more than one blood gas taken.

Sponsors

Sarah Gow
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

All patients with an acute respiratory illness who would normally have arterial blood gases done as part of their routine care will be deemed appropriate to be included in the study.

Exclusion criteria

Patients under 18 years of age. Pregnant patients (respiratory physiology changes considerably in pregnancy and may confound results)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026