None listed
Conditions
Brief summary
Gout is a major problem in New Zealand. High levels of uric acid in the blood are the cause of gout. Fructose is a sugar that is found in many fruits and honey. It has been shown that fructose can increase blood uric acid levels and thus contribute to gout. We currently recommend that people with gout reduce their intake of fructose to help improve their gout. About 20% of people do not absorb fructose in the gut. This can lead to abdominal symptoms. For people who do not absorb fructose, reducing fructose intake is not likely to be so important in controlling their gout. The aim of this study is to find out if people with gout are more likely to absorb fructose than people without gout.
Interventions
100 patients with gout will be recruited. Patients will be seen on one occasion to undertake a fructose breath test. Patients will be instructed to follow a low-fermentable diet for 24 hours prior to the test. Patients will give a fasting breath test in the morning and then be given a solution of fructose to drink. Repeat breath test will be taken every 15mins for up to 3 hours. The number of additional tests will be determined on case by case basis
Malabsorption of fructose will be defined as
100 patients with gout will be recruited. Patients will be seen on one occasion to undertake a fructose breath test. Patients will be instructed to follow a low-fermentable diet for 24 hours prior to the test. Patients will give a fasting breath test in the morning and then be given a solution of fructose to drink. Repeat breath test will be taken every 15mins for up to 3 hours. The number of additional tests will be determined on case by case basis Malabsorption of fructose will be defined as breath hydrogen greater than/equal to10ppm above baseline for at least two consecutive 15 minute readings or one reading of greater than 20 ppm above baseline. For those patients who do not produce hydrogen (typically 10-15% of the general population) methane will also be determined and similar cut offs concentrations will be used. Hydrogen and methane concentrations will be determined using a Quintron microlyser DP. This equipment is a purpose built hydrogen and methane analyser that uses solid state sensors to determine respective gas concentrations. This machine has been used for diagnostic purposes in Christchurch for over three years and is overseen by Scientific Officer Dr Bruce Dobbs. A/Prof Gearry has five years experience in overseeing, interpreting and reporting hydrogen and methane breath tests.
Sponsors
University of Otago, Christchurch
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Male or female aged >/=18 years 2. Patients fulfil the ACR preliminary classification criteria for gout (Wallace et al. 1977) 3. Subjects are willing and able to participate in the study and from whom written informed consent has been obtained.
Exclusion criteria
1. Known inflammatory bowel disease or irritable bowel syndrome 2. Receiving diuretic or antibiotic therapy 3. Presence of chronic infection or other severe concomitant medical illness or psychiatric disease. 4. Patients with active, concomitant malignancies.
Outcome results
None listed