None listed
Conditions
Brief summary
A randomized, parallel-designed, controlled trial to compare the long-term effects of consuming sugar-sweetened soft drink to the effects of consuming an equivalent amount (isocaloric, equal fructose) of fruit on serum uric acid and other risk factors for the metabolic syndrome in overweight individuals. Participants will be allocated to consume soft drink (1 L/d) or fruit (5 pieces/d) for 4 weeks. Metabolic risk factors will be measured at 0 and 4 weeks. Acute effects of soft drink (600 mL) and fruit intake (3 pieces) will also be measured using a crossover design
Interventions
Each participant will participate in the acute crossover intervention. Once this is completed each participant will then be randomised to one of two intervention groups in a long-term parallel intervention trial, to be commenced immediately:
Acute crossover intervention: On day one participants will attend a clinic where they will be randomly assigned to consume either 600 ml of sugar-sweetened soft drink (600mL) or fruit (3 pieces) after an overnight fast. Between 2 and 5 days later (depending
Each participant will participate in the acute crossover intervention. Once this is completed each participant will then be randomised to one of two intervention groups in a long-term parallel intervention trial, to be commenced immediately: Acute crossover intervention: On day one participants will attend a clinic where they will be randomly assigned to consume either 600 ml of sugar-sweetened soft drink (600mL) or fruit (3 pieces) after an overnight fast. Between 2 and 5 days later (depending on the participant's availability) they will receive the other treatment. Long-term parallel intervention: Each participant will be randomly allocated to consume an equivalent amount (isocaloric, equal fructose) of sugar-sweetened soft drink (1 L, provided by the trial investigators) or fruit (5 pieces, provided by the trial investigators) each day for 4 weeks
Sponsors
Professor Jim Mann
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Overweight but otherwise apparently healthy adults (Body Mass Index (BMI) over or equal to 28)
Exclusion criteria
Established diabetes, liver or kidney disease, gout or a history of other major chronic illnesses; diagnosed mental disorders; current use of medications affecting blood pressure, blood lipids, blood glucose or mood/mental state; currently pregnant or breastfeeding; intolerance to fruit or fructose; unable to remain in Dunedin, NZ for the duration of the intervention period
Outcome results
None listed