Obtaining thrombelastography (TEG) measurements for healthy pregnant mothers and applying the results to help manage major bleeding following birth.

In healthy women at term (gestation > 37 weeks), how do reference values for activated (kaolin and RapidTEG(Registered Trademark)) thromboelastogram parameters compare with reference values using a non-activated (native) assay and how these reference values can determine reference intervals.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000867897

Enrollment

Registered

2012-08-16

Start date

2010-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This observational study measures thrombelastography (TEG) values for healthy, non-labouring, pregnant women at term. These values are analysed to provide pregnancy-specific normal range for the TEG. These normal ranges can be applied to assist with making treatment decisions during a major bleed following birth.

Interventions

All participants provided a single venous specimen which underwent simultaneous analyses using three different assays; Native, Kaolin-activated and RapidTEG-activated. A specimen was obtained immediately prior to caesarean. Specimens were analysed using a dedicated TEG(registered Trademark) device. Processing is undertaken at the point-of-collection on 3 available channels.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Healthy pregnancy at term (> 37 weeks gestation)

Exclusion criteria

History of excessive bleeding Coagulation abnormalities Pregnancy-induced hypertension Haematocrit < 0.31 Platelet count < 100 x 10 Abnormal liver functions Recent anticoagulant therapy Recent antiplatelet therapy

Outcome results