Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block, with and without adrenaline, for gynaecologic surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000842864

Enrollment

Registered

2012-08-10

Start date

2012-09-10

Completion date

2013-03-18

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will investigate the effect of including a small amount of adrenaline in the local anaesthetic (ropivacaine) solution used for the abdominal wall nerve blocks commonly performed now to provide pain relief after abdominal surgery. Ropivacaine is commonly used for these nerve blocks because it is a longer-acting local anaesthetic. Adrenaline is a naturally occurring substance in the human body. It is commonly added to local anaesthetics to increase the duration of their effect, and to reduce the rate local anaesthetic is taken up into the blood stream (to limit the risk of side effects to the local anaesthetic). The specific purpose of this study is to determine how much, if at all, the inclusion of adrenaline reduces uptake of the local anaesthetic ropivacaine, with these particular blocks, and thus whether or not it increases the safety. Currently, adrenaline is routinely added to local anaesthesics for certain types of nerve blocks but its potential safety benefit in abdominal wall blocks using ropivacaine is unclear.

Interventions

Ultrasound-guided transversus abdominis plane block using ropivacine 0.2% (3mg/kg) with adrenaline 1:400,000 added, for postoperative analgesia after gynaecologic surgery

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Female patients more than 18 years of age undergoing elective gynaecological surgery and who are planned to receive transversus abdominis plane blocks will be included.

Exclusion criteria

Patients will be excluded if they have any allergy/sensitivity to local anaesthetic, infection at the site of block placement, pre-existing neurologic or muscular disease, bleeding tendency or evidence of coagulopathy, significant renal or liver dysfunction, or are pregnant.

Outcome results