Effect of a high potassium diet on endothelial function

Effect of a high potassium diet on endothelial function of healthy persons

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000822886

Enrollment

Registered

2012-08-06

Start date

2013-03-12

Completion date

2013-05-27

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to determine the effect of a high potassium diet on blood vessel function. A high potassium intake is associated with reduced risk of heart disease however effect of potassium on blood vessel function is not known. We propose increased dietary potassium will improve blood vessel function.

Interventions

This is a randomised crossover study of a 1week diet high in potassium (5690mg or 150mmol/day) versus a 1 week usual potassium (3110mg or 80mmol/day) diet with no washout between diets. Dietary targets are acheived by substituting serves of pasta/rice with serves of potatoes and apples with bananas each day.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

BMI greater than 18kg/m2 and less than 30kg/m2 SBP <130mmHg DBP<90mmHg weight stable for 6months

Exclusion criteria

Use of antihypertensive medication, systemic steroids, folate supplementation or non-steroidal antiinflammatory drugs. Metabolic disease such as liver or kidney disease. Treated hypertension. Previous clinical cardiovascular disease. Unable to comprehend protocol.

Outcome results