None listed
Conditions
Brief summary
The peak plasma propofol levels of endoscopy patients (Derived mathematically from the 3 measurements) along with the context sensitive half time of propofol (determined by the length of infusion) will allow the researchers to determine the time taken for plasma propofol levels to drop below levels known to cause driving impairment and thus estimate how long it takes for patients to drive safely after receiving a propofol only anaesthetic.
Interventions
Patients will receive propofol-only anaesthesia using the intermittent bolus technique.
Propofol will be administered through an intravenous cannula using the intermittent bolus technique (large loading bolus followed by small frequent boluses) which titrates dosage to adequate sedation.
The anaesthetist looking after the patient will give a propofol-only anaesthetic as per his or her usual procedure. The timing and dosage of boluses will not be stipulated by the researchers.
The loading dos
Patients will receive propofol-only anaesthesia using the intermittent bolus technique. Propofol will be administered through an intravenous cannula using the intermittent bolus technique (large loading bolus followed by small frequent boluses) which titrates dosage to adequate sedation. The anaesthetist looking after the patient will give a propofol-only anaesthetic as per his or her usual procedure. The timing and dosage of boluses will not be stipulated by the researchers. The loading dose is given immediately prior to commencing the endoscopy. Further boluses are given when deemed required by the anaesthetist.
Sponsors
Monash Medical Centre
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Undergoing colonoscopy or gastroscopy
Exclusion criteria
ASA 3 or 4
Outcome results
None listed