Ramosetron, low dose midazolam, and their combination for the prevention of postoperative nausea and vomiting in patients undergoing thyroidectomy

In patients undergoing thyroidectomy, which is more effective for the prevention of postoperative nausea and vomiting among ramosetron, low dose midazolam, and their combination?

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000757819

Enrollment

Registered

2012-07-16

Start date

2012-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Postoperative nausea and vomiting (PONV) frequently develops in patients undergoing thyroidectomy, The present study was undertaken to compare the effects of ramosetron, low dose midazolam, and their combination on PONV in patients following total thyroidectomy. Patients were randomly assigned to one of three groups to receive antiemetics as follows: ramosetron 0.3 mg, low dose nidazolam 75microg/kg, or their combination. PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0, 6, 12, 24h postoperatively.

Interventions

Before induction of anesthesia, ramosetron 0.3 mg combined with low dose midazolam(75 microg/kg) is injected

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

patients undergoing thyroidectimy

Exclusion criteria

severe impairment of bowel motility, insulin-dependent diabetes mellitus, pregnancy or breast feeding, administration of antiemetic medication within 24 h before operation, history of cardiovascular or respiratory disease, active alcohol or drug usage, obesity (body mass index > 35 kg/m2), impaired renal and/or hepatic function

Outcome results