None listed
Conditions
Brief summary
Heart surgery is a common procedure, with more than 2500 operations each year in New Zealand. Damage to organs, including kidneys, liver and heart is common after heart surgery and some of the damage may be caused by extra oxygen given on cardiopulmonary bypass. This study will randomise patients to receive normal levels of oxygen or the traditional high levels during heart surgery. Endpoints include a number of blood tests that are very sensitive for detecting damage to the kidney, liver, heart and other organs. In total 286 patients having heart surgery at Auckland City Hospital will be included in this study over a two year period.
Interventions
During anaesthesia SpO2 will be kept at 92-95% and during CPB the oxygen tension of the arterial return blood flow will be kept at 10 - 12 kPa using continuous in-line real-time blood gas monitoring (Terumo CDI 500, Terumo Corporation).
Sponsors
Dr Shay McGuinness
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
16 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
Adult patient (over 16 yrs) Scheduled to have cardiac surgery using cardiopulmonary bypass Written informed consent obtained
Exclusion criteria
Preoperative acute renal failure within 6 weeks (acute rise in serum creatinine >50% from baseline) is present or Pre-operative end stage renal disease (serum creatinine >300 µmol/L) is present or receiving any form of renal replacement therapy or Pre-operative hepatic dysfunction (AST> 2* upper limit of normal) or Recent (< 6 weeks) cerebrovascular event, (Including CVA,TIA or intracerebral bleed) or Pregnant
Outcome results
None listed