The effect of saffron supplementation on vision in patients with early dry age-related macular degeneration

Patients with atrophic age-related macular degeneration and the effect of saffron supplementation compared with placebo in improving visual and electrophysiological outcomes

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000729820

Enrollment

100

Registered

2012-07-09

Start date

2013-01-09

Completion date

2014-11-10

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Age-related macular degeneration (AMD) is a common cause of visual loss in older people, and currently treatment options for dry AMD are limited. This study will investigate whether saffron supplements are an effective treatment for dry AMD.

Interventions

Oral Saffron supplementation with 20 mg daily for a 3 month period with possible time period extension based on results. There is no wash out period.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

45 Years to 90 Years

Healthy volunteers

Inclusion criteria

Clinical diagnosis of age-related macular degeneration (AMD) as determined by a qualified retinal specialist Ability to participate in electroretinographic examination

Exclusion criteria

Significant ocular media opacities Other retinal disease (i.e. diabetes, glaucoma, retinal vascular disease) Neovascular AMD Presence of small bowel or liver disease impairing oral tablet absorption

Outcome results