None listed
Conditions
Brief summary
During surgery on the bowel it is routine to replace blood and fluid loss with intravenous fluids. However, it is still unclear what the optimal amount and method is to replace this loss. This study compares giving a smaller amount of fluid, called fluid restriction, to giving fluid guided by a cardiac output monitor, called targetted fluid administration. We will assess the impact these two methods have on patient's recovery and also the effect on observed clinical signs such as cardiac output at the end of the operation.
Interventions
The fluid optimisation group will have an oesophageal doppler inserted after induction. A maintenance rate of Hartmann's solution at 6mls/kg/hr will run intravenously at the start to the end of the operative period. The anaesthetist will use the oesophageal doppler to administer colloid boluses intravenously (250mls Hydroxyethyl starch 130/0.4, Volulyte, Fresenius Kabi) based on the stroke volume and flow time parameters.
Sponsors
Dr Tuong Dien Phan
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Elective major colorectal surgery >18yrs of age Enrollment into the Enhance Recovery After Surgery clinical care pathway.
Exclusion criteria
Emergency surgery Significant renal impairment Hepatic dysfunction Oesophageal pathology that is a contraindication to a oesophageal doppler probe Inability to give informed consent Pregnancy
Outcome results
None listed