None listed
Conditions
Brief summary
Gentamicin can have toxic effects on the inner ear which lessen an individual’s sense of spatial orientation and balance. The aim of this study is to investigate the incidence of this form of toxicity, and to investigate to what extent recovery is possible. This is done by recording eye movements, which have characteristic properties when movement sensors in the inner ear are non-functional. This study will use video-oculography to enable an objective serial recording of the eye movement abnormality. In selected patients, the eye movements will be recorded over 6 months to observe recovery. This will provide information on how quickly the vestibular-ocular reflex (VOR) function recovers.
Interventions
Impairment of the vestibulo-ocular reflex following the administration of Gentamicin. This will be monitored daily, ideally pre-treatment, during the course of all IV treated patients with ANY dose of Gentamicin and at 7 days following completion of treatment. Recovery of any defecit will be monitored for up to 6 months in patients who show signs of impaired vestibular function.
Sponsors
Capital and Coast District Health Board (CCDHB)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Participants must: be able to give consent prior to or while being treated at Wellington Hospital or Hutt Valley Hospital. The only inclusion criteria at day 1 will be treatment or pending treatment with IV Gentamicin within 24 hrs of measurement of the VOR gain.
Exclusion criteria
Patients so unwell that they do not wish to have their head moved or who decline testing or who are regarded by the examiner as being too ill to adequately co-operate.
Outcome results
None listed