A study of the effect of preoperative chemoradiotherapy on sexual dysfunction in men with locally advanced rectal cancer

A single arm prospective study of the effect of preoperative chemoradiotherapy on sexual dysfunction in men with locally advanced rectal cancer

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000669897

Enrollment

Registered

2012-06-22

Start date

2012-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is designed to assess rate of sexual dysfunction in men following treatment with radiotherapy and surgery for rectal cancer. It aims to identify potential causes of sexual dysfunction in this group of patients, including assessing testicular hormone function following this treatment.

Interventions

Observational Study of male sexual dysfunction. Duration of observation 18 months. Assessments will be made at baseline (before radiotherapy) and at 3, 6,9, 12 and 18 months following radiotherapy.

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1.Age >18years 2.Male 3.Histologically confirmed rectal adenocarcinoma 4. Stage T3-4N0 or N1 disease 5. Requires pre-operative radiotherapy or chemoradiotherapy followed by TME resection 6. Provide informed consent 7. Able to complete sexual function and quality of life questionnaire

Exclusion criteria

1. Prior pelvic radiotherapy 2. History of impotence 3. Inflammatory bowel disease 4. Prior pelvic surgery 5. Receiving hormonal treatment for prostate cancer 6. Patients taking testosterone supplements

Outcome results