None listed
Conditions
Brief summary
It is well known that being physically active is important for maintaining good health. However, new evidence has emerged showing that being sedentary (sitting for prolonged periods) is adversely associated with indicators of poor health, such as elevated blood glucose and blood fats. Recent experimental evidence suggests that breaking up sitting time throughout the day with light-intensity activity (ie. walking) results in lower blood glucose and blood fat levels than sitting for prolonged periods without activity breaks. However, it is not known whether short-duration bouts of standing, of comparable frequency, can elicit similar metabolic benefits to those observed with treadmill walking. Consequently, this study aims to test the acute (7-hour) effect of prolonged sitting on glucose metabolism and vascular function with and without intermittent breaks of standing.
Interventions
The experimental condition involves a single day of prolonged sitting (total duration= 7hrs) with intermittent bouts of short-duration standing. Participants will remain seated for the initial 140min (steady state) period, after which they will consume a standardised mixed meal (50g fat, 75g carbohydrate) and will complete a 2min bout of standing every 20mins for the remaining 5 hours (total standing duration:28mins). All activities will take place in a controlled laboratory environment under t
The experimental condition involves a single day of prolonged sitting (total duration= 7hrs) with intermittent bouts of short-duration standing. Participants will remain seated for the initial 140min (steady state) period, after which they will consume a standardised mixed meal (50g fat, 75g carbohydrate) and will complete a 2min bout of standing every 20mins for the remaining 5 hours (total standing duration:28mins). All activities will take place in a controlled laboratory environment under the supervision of trained clinical research staff. During the condition, participants will be permitted to watch television, DVD’s or read. In this trial, participants will complete each condition (experimental and control) in random order, with a minimum 7 day washout period between conditions.
Sponsors
Baker IDI Heart and Diabetes Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria includes: overweight or obesity (body mass index greater than or equal to 25kg/m2 but less than or equal to 45kg/m2) and English speaking
Exclusion criteria
Exclusion is based on: of pregnancy; employment in a non-sedentary occupation (< 5 hours total sitting during the typical workday); currently watching < 3 hours of total screen (including television, computer or electronic games) time per day; regularly engaged in moderate-vigorous physical activity greater than or equal to 150min/week > 3 months; use of carbohydrate or lipid-lowering medication; greater than or equal to 5 previous vasovagal syncope episodes or epilepsy; known physical activity contraindications; major illness/injury (acute or chronic), smokers; orthostatic intolerance, and the use of aspirin or other anticoagulants.
Outcome results
None listed