None listed
Conditions
Brief summary
The purpose of this study is to determine heart function in pregnant women after they are treated for the disease of preeclampsia. The reason to do this is that the drug treatments that are used to control the high blood pressure in this disease have not been examined with respect to how they alter heart function in these sick pregnant women.
Interventions
Observations of cardiac function using transthoracic echocardiography at the time of treatment interventions. Transthoracic echocardiography will be performed prior to and after treatment interventions and also after the intervention of passive leg raising to assess stroke volume changes. Transthoracic echocardiography will also be performed in healthy pregnant women at rest and during passive leg raising. Transthoracic echocardiography examination will take approximately 15 minutes. The post-in
Observations of cardiac function using transthoracic echocardiography at the time of treatment interventions. Transthoracic echocardiography will be performed prior to and after treatment interventions and also after the intervention of passive leg raising to assess stroke volume changes. Transthoracic echocardiography will also be performed in healthy pregnant women at rest and during passive leg raising. Transthoracic echocardiography examination will take approximately 15 minutes. The post-intervention measurements will occur within 60 minutes of the drug being administered.
Sponsors
The Royal Women's Hosptial
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Women with preeclampsia - non-labouring women, non-smokers, no vasoactive treatments or intravenous fluids adninstered, no previous cardiac disease or uterine abnormality. Healthy pregnant women - non-labouring women, no significant medical or surgical illness, non smokers, no uterine abnormalities and normally defined placentation. They will not be receiving any vasoactive medication including salbutamol or thyroid replacement hormones.
Exclusion criteria
labouring women, current administration of vasoactive drugs including salbutamol and thyroxine, pre-existing or gestational diabetes, smoking, and a known uterine abnormality.
Outcome results
None listed