Can blood levels of Endothelin-1 predict liver function after liver resection?

A study to determine whether serum levels of Endothelin-1 have any prognostic utility in predicting liver function post liver resection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000604808

Enrollment

Registered

2012-06-05

Start date

2010-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Postoperative liver failure (PLF) remains a relatively frequent and life-threatening complication after liver resection. Recent studies have demonstrated that besides the residual liver volume, damage of the microcirculation secondary to increased portal blood flow is a main determinant of PLF. Endothelin-1 (ET-1) is a multimodular mediator produced primarily by sinusoidal endothelial cells and is known to play a key role in the regulation of hepatic microcirculation and ischemia reperfusion injury. The aim of this study was to determine whether ET-1 levels has any prognostic utility in predicting PLF.

Interventions

Prospective study, post operative liver functional test and serum level of endothelin 1 and TNF are measured preoperatively an post operative day 1, 2 ,5

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

Liver resection

Exclusion criteria

no liver resection

Outcome results