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Treatment of irritable bowel syndrome: Using dietary carbohydrate restriction and hypnotherapy as complementary therapies

Treatment of irritable bowel syndrome: Using dietary carbohydrate restriction and hypnotherapy as complementary therapies

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12612000585820
Enrollment
78
Registered
2012-05-30
Start date
2012-07-01
Completion date
2014-10-31
Last updated
2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Current treatment strategies of IBS are unsatisfactory. Currently there are three common modes of treatment for IBS including: drugs, diet and psychological therapies. Pharmacologic interventions are generally not effective in treating IBS and no drug has been shown to relieve the full spectrum of gastrointestinal symptoms that make up IBS. Two common modes of treatment, however, that have been scientifically proven to relieve the symptoms of IBS include hypnotherapy and the low FODMAP diet. Gut-focused hypnotherapy uses hypnosis to induce a deep state of relaxation allowing the subconscious mind to become highly receptive to suggestions directed towards the control and normalisation of gut function. Recently published scientific research has shown that gut-focused hypnotherapy can have a 70+% success rate in the reduction of abdominal symptoms including abdominal pain, bloating, constipation and diarrhoea. Additionally, gut-focused hypnotherapy has been shown to improve overall well-being and quality of life, reduce anxiety and depression and reduce medication needs. Furthermore, these improvements have been shown to be maintained for 2-5 years. FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols) are a group of dietary sugars that can be poorly absorbed in people with IBS. When these sugars are poorly absorbed in the small intestine they continue along the gastrointestinal tract and arrive at the large intestine where they act as a food source to the bacteria that normally live there. The bacteria of the large intestine then ferment these FODMAPs and can cause symptoms of IBS. Recently published scientific research has shown that dietary restriction of these poorly absorbed FODMAP sugars (the low FODMAP diet) can have a 75% success rate in the reduction of abdominal symptoms including abdominal pain, bloating, constipation and diarrhoea. Additionally, the low FODMAP diet has been shown to improve levels of fatigue amongst this population. While both the low FODMAP diet and hypnotherapy significantly reduce symptoms in the majority of IBS patients, the benefit of combining these therapies has not yet been investigated. It is anticipated that this study will shed light on the benefit of applying these therapies both individually and in combination with one another, allowing GPs and gastroenterologists to direct IBS patients to the best available treatment which may be tailored to each individual patient. Aims To assess the effectiveness of using dietary carbohydrate restriction (the low FODMAP diet) and hypnotherapy as complimentary therapies for the effective management of IBS To compare the combined treatment of the low FODMAP diet and hypnotherapy to each of the standalone therapies To assess the long term effectiveness of each of the treatment conditions Hypotheses Hypnotherapy will improve IBS symptom severity and psychological status amongst the IBS population The low FODMAP diet will improve IBS symptom severity and psychological status amongst the IBS population Hypnosis and the low FODMAP diet as complimentary therapies will improve IBS symptom severity and psychological status to a greater extent than if these two therapeutic modalities were administered independently Improvements in IBS symptom severity and psychological status will be maintained at 3 and 6 months following each of the treatment conditions

Interventions

Participants are randomised to receive one of three treatment conditions: 1. Hypnotherapy Hypnotherapy sessions are one hour in duration and will occur weekly for a total of six weeks. Hypnotherapy sessions will be delivered by a registered clinical hypnotherapist, Ms Simone Peters who has specific training and knowledge in using hypnotherapy for the treatment of IBS. Each participant will receive the same information in each of the hypnotherapy sessions. Participants will also be required to li

Participants are randomised to receive one of three treatment conditions: 1. Hypnotherapy Hypnotherapy sessions are one hour in duration and will occur weekly for a total of six weeks. Hypnotherapy sessions will be delivered by a registered clinical hypnotherapist, Ms Simone Peters who has specific training and knowledge in using hypnotherapy for the treatment of IBS. Each participant will receive the same information in each of the hypnotherapy sessions. Participants will also be required to listen to a daily hypnosis audiotape. This audiotape will be a recording of the first hypnosis session. 2. Low FODMAP (fermentable, oligosaccharides, disaccharides, monosaccharides and polyols) dietary intervention The low FODMAP dietary intervention will consist of a one hour initial dietary consultation in week one and a review consultation in week six. The low FODMAP diet will be taught by a practicing dietitian, Dr Sue Shepherd who has specific training and knowledge in using the low FODMAP diet for the treatment of IBS. Each participant will receive the same information in the initial and follow up dietary consultations. 3. Combination of both hypnotherapy and low FODMAP diet The combination treatment condition will include one hour, weekly hypnotherapy sessions for six weeks; one hour initial dietary consultation in week one and review consultation in week six. The hypnotherapy and low FODMAP interventions will be given simultaneously. Each participant receives the same information in each of the hypnotherapy sessions becuase the sessions are scripted. Therefore, once the participant has entered a state of hypnosis they are essentially read the same 'script' as every other participant in the hypnotherapy condition. Participants in the low FODMAP treatment condition will be provided with information about the low FODMAP diet i.e. what the low FODMAP diet is, what foods are 'safe' on the low FODMAP diet etc Participants are then required to utilise the diet themselves. The dietitan, Dr Sue Shepherd will have weekly telephone contact with participants to ensure compliance.

Sponsors

Monash University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

18 years old, met Rome III criteria for IBS, coealic disease excluded by normal duodenal biopsy or HLA DQ2 (human leukocyte antigen) and HLA DQ8 (human leukocyte antigen) negative

Exclusion criteria

Marsh 1 or 2 lesions, other significant gastrointestinal disease (e.g. cirrhosis, inflammatory bowel disease), other clinically significant co-morbidity, psychiatric disease, pregnancy, alcoholism

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026