Coenzyme Q10 for Alleviation of the Fatigue of Post Polio Syndrome

Oral supplementation of polio survivors with Post Polio Syndrome or Late Effects of Polio by coenzyme Q10 for relief of their excessive fatigue, as measured by fatigue questionnaires.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000552886

Enrollment

103

Registered

2012-05-24

Start date

2012-11-06

Completion date

2013-09-09

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of the clinical trial is to determine whether taking a 100 mg capsule of coenzyme Q10 daily for a period of two months can alleviate the excessive fatigue of Post Polio Syndrome or Late Effects of Polio. This will be tested in a randomised, double-blind, placebo-controlled trial at the Griffith Clinical Trials Unit. Fatigue will be assessed by two fatigue questionnaires to be filled out by the participants before the start of the trial (baseline) and after the two-month period of taking capsules. Coenzyme Q10 blood levels will also be determined to confirm compliance and to validate the findings. Statistical analysis of the questionnaires will be undertaken by a biostatistician.

Interventions

Oral supplementation by 100 mg capsule of CoQ10 daily for a period of 2 months

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Polio survivors with Post Polio Syndrome or the Late Effects of Polio who attribute their excessive fatigue primarily to PPS/LEOP

Exclusion criteria

Diagnosis with another medical condition that may account for the excessive fatigue, e.g. diabetes, anaemia, thyroid deficiency or fibromyalgia. Treatment with warfarin since CoQ10 can redcue its effectiveness. Those already taking CoQ10 on a regular basis

Outcome results