The effect of intravenous lidocaine infusion on the pain after subtotal gastrectomy

In patients undergoing subtotal gastrectomy, is intravenous lidocaine infusion effective in reducing post-operative pain?

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000545864

Enrollment

Registered

2012-05-22

Start date

2012-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Intravenous lidocaine infusion in various type of surgery is known to effective in reducing post-operative pain, analgesic requirements, the stress response and lengthens the period to first post-operative analgesic requirement. We hypothesized that intravenous lidocaine infusion reduce the pain after subtotal gastrectomy. Therefore we performed a study to investigate the effectiveness of lidocaine on pain after subtotal gastrectomy .

Interventions

Intravenous (IV) lidocaine infusion:group: IV administration of 1mg/ml lidocaine was performed 2 minute before orotracheal intubation. Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) followed by a continuous IV infusion of lidocaine at 2 mg/kg/hr during the operation (150-180 min).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

patients undergoing subtotal gastrectomy

Exclusion criteria

body weight lower than 45 kg or greater than 100 kg, history of severe underlying cardiovascular, pulmonary, renal or hepatic disease, or allergy to local anaesthetics

Outcome results