Paracetamol Rectal Suppository for postoperative pain reduction in Abdominal Hysterectomy A Randomized controlled trial

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Paracetamol in conjunction with strong opioids such as morphine shown to reduce the amount of opioid used and improve analgesic effect. Paracetamol has many available forms such as oral injection and suppository. In the first 24 hours after surgery, women were not allowed to have any ingestion, except intravenous solution. Therefore, paracetamol rectal suppository was add with strong opioids (morphine or pethidine) routinely postoperative painkillers for postoperative pain relief. The aims of adding paracetamol rectal suppository were to reduce opioids consumption and avoid their adverse effects, e.g. nausea and/or vomiting, orthostatic hypotension and respiratory compression. We therefore would like to study the effectiveness and safety of paracetamol rectal suppository in pain reduction in women undergoing total abdominal hysterectomy. We hypothesized that paracetamol rectal suppository can reduce postoperative pain in abdominal hysterectomy more effective than placebo. The primary outcome was postoperative pain score and the secondary outcome was volume of opioids consumption.

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